I recommend you to simply start and post here, once you run into any issues.
There is a lot of Audio Software available in KaOS, like Muse-sequencer, Ardour, KWave and so on.
Jack and Jack2 is also here, qjackctl help you to organize that one.
Such things show their challenges often in practice, as an example on the Firewire interface in my case.
We are here to help you in any case